Pathologic comparison of asymmetric or sulcus fixation of 3-piece intraocular lenses with square versus round anterior optic edges
Identifieur interne : 001964 ( Main/Exploration ); précédent : 001963; suivant : 001965Pathologic comparison of asymmetric or sulcus fixation of 3-piece intraocular lenses with square versus round anterior optic edges
Auteurs : Andrew Ollerton [États-Unis] ; Liliana Werner [États-Unis] ; Susan Strenk [États-Unis] ; Lawrence Strenk [États-Unis] ; Lisa Leishman [États-Unis] ; Zachary Bodnar [États-Unis] ; Kevin R. Kirk [États-Unis] ; Jennifer Michelson [États-Unis] ; Nick Mamalis [États-Unis]Source :
- Ophthalmology [ 0161-6420 ] ; 2013.
Abstract
To evaluate pathologic findings of 3-piece intraocular lenses (IOLs) with asymmetric or sulcus fixation in pseudophakic cadaver eyes, comparing IOLs with square or round edges on the anterior optic surface.
Comparative case series with pathology.
661 pseudophakic cadaver eyes obtained from eye banks within the United States, implanted with different IOLs
Anterior segment scanning of whole eyes with a high-frequency ultrasound system, or with a high-resolution anterior segment magnetic resonance imaging, followed by gross examination. Selected eyes were processed for complete histopathologic analysis.
Findings from imaging, gross, and histopathologic evaluation that could be related to out-of-the-bag fixation of the lenses.
Out of 661 pseudophakic cadaver eyes obtained, 13 had 3-piece hydrophobic acrylic IOLs with anterior and posterior square optic edges, and 14 had 3-piece lenses with anterior round edges (13 silicone lenses, and 1 hydrophobic acrylic lens) without symmetric in-the-bag fixation. These 27 selected eyes were processed for complete histopathologic analysis. Gross findings in both groups were composed of IOL decentration and tilt, pigmentary dispersion within the anterior segment and on the IOL surface, and iris transillumination defects. Histopathology of the 14 eyes with 3-piece IOLs with round anterior optic edges showed mild focal disruption of the iris pigmented layer, and loop protrusion/erosion in the ciliary sulcus. Additional changes observed in the 13 eyes with square anterior optic edge IOLs included iris changes such as vacuolization, disruption and loss of the pigmented epithelial layers, iris thinning and atrophy, synechiae, and pigmentary dispersion within the trabecular meshwork. One eye also exhibited initial signs of optic nerve disc cupping.
In this series, pathologic findings were more severe in eyes implanted with 3-piece IOLs with square anterior optic edges, suggesting that IOLs with round anterior edges are more suitable for sulcus fixation.
Url:
DOI: 10.1016/j.ophtha.2013.01.029
PubMed: 23597794
PubMed Central: 3718860
Affiliations:
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Moran Eye Center, University of Utah, Salt Lake City, UT, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>John A. Moran Eye Center, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name><affiliation wicri:level="2"><nlm:aff id="A1">John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>John A. Moran Eye Center, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Strenk, Susan" sort="Strenk, Susan" uniqKey="Strenk S" first="Susan" last="Strenk">Susan Strenk</name><affiliation wicri:level="2"><nlm:aff id="A2">MRI Research, Inc., Cleveland, OH, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>MRI Research, Inc., Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Strenk, Lawrence" sort="Strenk, Lawrence" uniqKey="Strenk L" first="Lawrence" last="Strenk">Lawrence Strenk</name><affiliation wicri:level="2"><nlm:aff id="A2">MRI Research, Inc., Cleveland, OH, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>MRI Research, Inc., Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Leishman, Lisa" sort="Leishman, Lisa" uniqKey="Leishman L" first="Lisa" last="Leishman">Lisa Leishman</name><affiliation wicri:level="2"><nlm:aff id="A1">John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>John A. Moran Eye Center, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Bodnar, Zachary" sort="Bodnar, Zachary" uniqKey="Bodnar Z" first="Zachary" last="Bodnar">Zachary Bodnar</name><affiliation wicri:level="2"><nlm:aff id="A1">John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>John A. Moran Eye Center, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Kirk, Kevin R" sort="Kirk, Kevin R" uniqKey="Kirk K" first="Kevin R" last="Kirk">Kevin R. Kirk</name><affiliation wicri:level="2"><nlm:aff id="A1">John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>John A. Moran Eye Center, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author><author><name sortKey="Michelson, Jennifer" sort="Michelson, Jennifer" uniqKey="Michelson J" first="Jennifer" last="Michelson">Jennifer Michelson</name><affiliation wicri:level="2"><nlm:aff id="A1">John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>John A. Moran Eye Center, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="A3">Tufts Medical School, Boston, MA, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Tufts Medical School, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mamalis, Nick" sort="Mamalis, Nick" uniqKey="Mamalis N" first="Nick" last="Mamalis">Nick Mamalis</name><affiliation wicri:level="2"><nlm:aff id="A1">John A. Moran Eye Center, University of Utah, Salt Lake City, UT, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>John A. Moran Eye Center, University of Utah, Salt Lake City, UT</wicri:regionArea><placeName><region type="state">Utah</region></placeName></affiliation></author></analytic><series><title level="j">Ophthalmology</title><idno type="ISSN">0161-6420</idno><idno type="eISSN">1549-4713</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P1">To evaluate pathologic findings of 3-piece intraocular lenses (IOLs) with asymmetric or sulcus fixation in pseudophakic cadaver eyes, comparing IOLs with square or round edges on the anterior optic surface.</p></sec><sec id="S2"><title>Design</title><p id="P2">Comparative case series with pathology.</p></sec><sec id="S3"><title>Participants</title><p id="P3">661 pseudophakic cadaver eyes obtained from eye banks within the United States, implanted with different IOLs</p></sec><sec id="S4"><title>Methods</title><p id="P4">Anterior segment scanning of whole eyes with a high-frequency ultrasound system, or with a high-resolution anterior segment magnetic resonance imaging, followed by gross examination. Selected eyes were processed for complete histopathologic analysis.</p></sec><sec id="S5"><title>Main Outcome Measures</title><p id="P5">Findings from imaging, gross, and histopathologic evaluation that could be related to out-of-the-bag fixation of the lenses.</p></sec><sec id="S6"><title>Results</title><p id="P6">Out of 661 pseudophakic cadaver eyes obtained, 13 had 3-piece hydrophobic acrylic IOLs with anterior and posterior square optic edges, and 14 had 3-piece lenses with anterior round edges (13 silicone lenses, and 1 hydrophobic acrylic lens) without symmetric in-the-bag fixation. These 27 selected eyes were processed for complete histopathologic analysis. Gross findings in both groups were composed of IOL decentration and tilt, pigmentary dispersion within the anterior segment and on the IOL surface, and iris transillumination defects. Histopathology of the 14 eyes with 3-piece IOLs with round anterior optic edges showed mild focal disruption of the iris pigmented layer, and loop protrusion/erosion in the ciliary sulcus. Additional changes observed in the 13 eyes with square anterior optic edge IOLs included iris changes such as vacuolization, disruption and loss of the pigmented epithelial layers, iris thinning and atrophy, synechiae, and pigmentary dispersion within the trabecular meshwork. One eye also exhibited initial signs of optic nerve disc cupping.</p></sec><sec id="S7"><title>Conclusion</title><p id="P7">In this series, pathologic findings were more severe in eyes implanted with 3-piece IOLs with square anterior optic edges, suggesting that IOLs with round anterior edges are more suitable for sulcus fixation.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li><li>Ohio</li><li>Utah</li></region></list><tree><country name="États-Unis"><region name="Utah"><name sortKey="Ollerton, Andrew" sort="Ollerton, Andrew" uniqKey="Ollerton A" first="Andrew" last="Ollerton">Andrew Ollerton</name></region><name sortKey="Bodnar, Zachary" sort="Bodnar, Zachary" uniqKey="Bodnar Z" first="Zachary" last="Bodnar">Zachary Bodnar</name><name sortKey="Kirk, Kevin R" sort="Kirk, Kevin R" uniqKey="Kirk K" first="Kevin R" last="Kirk">Kevin R. Kirk</name><name sortKey="Leishman, Lisa" sort="Leishman, Lisa" uniqKey="Leishman L" first="Lisa" last="Leishman">Lisa Leishman</name><name sortKey="Mamalis, Nick" sort="Mamalis, Nick" uniqKey="Mamalis N" first="Nick" last="Mamalis">Nick Mamalis</name><name sortKey="Michelson, Jennifer" sort="Michelson, Jennifer" uniqKey="Michelson J" first="Jennifer" last="Michelson">Jennifer Michelson</name><name sortKey="Michelson, Jennifer" sort="Michelson, Jennifer" uniqKey="Michelson J" first="Jennifer" last="Michelson">Jennifer Michelson</name><name sortKey="Strenk, Lawrence" sort="Strenk, Lawrence" uniqKey="Strenk L" first="Lawrence" last="Strenk">Lawrence Strenk</name><name sortKey="Strenk, Susan" sort="Strenk, Susan" uniqKey="Strenk S" first="Susan" last="Strenk">Susan Strenk</name><name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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